Sperm Donor's Hidden Cancer Gene Passed to Nearly 200 Children

A sperm donor carrying a rare, cancer-causing gene fathered nearly 200 children, a new report reveals. Many of the offspring have inherited the high-risk mutation. The gene significantly raises the lifetime risk of several cancers, including in the pancreas, skin, and uterus. Medical experts state only a minority of those who inherit it will avoid developing cancer in their lifetime. Some of the donor-conceived children have already died. The case highlights critical ethical and health gaps in donor screening. The donor was unaware of his genetic condition at the time of donations. Current guidelines often do not require the broad genetic testing that could detect such rare mutations. Families and individuals conceived with the donor's sperm are now being urgently notified. They are advised to seek genetic counseling and medical screening.